Recommanded Product: 350-30-1On March 13, 2019, Zhu, Xiao-Lei; Zhang, Rui; Wu, Qiong-You; Song, Yong-Jun; Wang, Yu-Xia; Yang, Jing-Fang; Yang, Guang-Fu published an article in Journal of Agricultural and Food Chemistry. The article was 《Natural product neopeltolide as a cytochrome bc1 complex inhibitor: Mechanism of action and structural modification》. The article mentions the following:
The marine natural product neopeltolide was isolated from a deep-water sponge specimen of the family Neopeltidae. Neopeltolide has been proven to be a new type of inhibitor of the cytochrome bc1 complex in the mitochondrial respiration chain. However, its detailed inhibition mechanism has remained unknown. In addition, neopeltolide is difficult to synthesize because of its very complex chem. structure. In the present work, the binding mode of neopeltolide was determined for the first time by integrating mol. docking, mol. dynamics simulations, and mol. mechanics Poisson-Boltzmann surface area calculations, which showed that neopeltolide is a Qo site inhibitor of the bc1 complex. Then, according to guidance via inhibitor-protein interaction anal., structural modification was carried out with the aim to simplify the chem. structure of neopeltolide, leading to the synthesis of a series of new neopeltolide derivatives with much simpler chem. structures. The calculated binding energies (ΔGcal) of the newly synthesized analogs correlated very well (R2 = 0.90) with their exptl. binding free energies (ΔGexp), which confirmed that the computational protocol was reliable. Compound 45, bearing a di-Ph ether fragment, was successfully designed and synthesized as the most potent candidate (IC50 = 12 nM) against porcine succinate cytochrome c reductase. The mol. modeling results indicate that compound 45 formed a π-π interaction with Phe274 and two hydrogen bonds with Glu271 and His161. The present work provides a new starting point for future fungicide discovery to overcome the resistance that the existing bc1 complex inhibitors are facing. In addition to this study using 3-Chloro-4-fluoronitrobenzene, there are many other studies that have used 3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Recommanded Product: 350-30-1) was used in this study.
3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Recommanded Product: 350-30-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics