Product Details of 350-30-1On September 2, 2020 ,《Synthesis, insecticidal evaluation and 3D-QASR of novel anthranilic diamides derivatives containing N-arylpyrrole as potential ryanodine receptor activators》 was published in Journal of Agricultural and Food Chemistry. The article was written by Wu, Changchun; Yu, Xiaobo; Wang, Baolei; Liu, Jingbo; Meng, Fanfei; Zhao, Yangyang; Xiong, Lixia; Yang, Na; Li, Yuxin; Li, Zhengming. The article contains the following contents:
The synthesis of novel anthranilic diamides derivatives I [R = HC, N, Cl-C; R4 = O2N, F3C, i-Pr, etc; R5 = Me, i-Pr] incorporating pyrrole moiety targeting at insect RyRs. The structures I were confirmed by 1H NMR, 13C NMR, 19F NMR and HRMS. The preliminary bioassay results indicated that most of the title compounds I showed good to excellent insecticidal activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). For oriental armyworm, I [R = N; R4 = H; R5 = Me] displayed the same level of larvicidal activity as the pos. control chlorantraniliprole, with the LC50 value of 0.21 mg/L. For diamondback moth II [R5 = Me; X = Br], [R5 = i-Pr; X = Br], [R5 = Me; X = Cl] and [R5 = i-Pr; X = Cl] exhibited higher insecticidal activities than chlorantraniliprole. In particular, In had 50% larvicidal activity at 0.00001 mg/L. Calcium imaging technique was applied to study the effect of I [R = N; R4 = H; R5 = Me] and II [R5 = Me; X = Br, Cl] on the intracellular calcium ion concentration ([Ca2+]i) in central neurons isolated from oriental armyworm. The results indicated that the tested compoundsI and II, like chlorantraniliprole was activate the insect ryanodine receptors. Furthermore, comparative mol. field (CoMFA) anal. and d. functional theory (DFT) calculations were carried out to study the structure-activity relationship (SAR).3-Chloro-4-fluoronitrobenzene(cas: 350-30-1Product Details of 350-30-1) was used in this study.
3-Chloro-4-fluoronitrobenzene(cas: 350-30-1) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Product Details of 350-30-1 Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics