Bamoro, Coulibaly; Bamba, Fante; Dindet Steve-Evanes, Koffi Teki; Aurelie, Vallin; Vincent, Chagnault published an article in 2021. The article was titled 《Design, synthesis and antibacterial activity evaluation of 4,5-diphenyl-1H-imidazoles derivatives》, and you may find the article in Open Journal of Medicinal Chemistry.Formula: C7H6BrCl The information in the text is summarized as follows:
Due to the continuous emergence and rapid spread of drug-resistant strains of bacteria, there is an urgent need for the development of novel antimicrobials. Herein, the synthesis and antibacterial activity of 4,5-diphenylimidazol-2-thiol derivatives I (R = Ph, 4-O2NC6H4, 2,4-Cl2C6H3, 5-R’-benzimidazol-5-yl, etc.; R’ = H, O2N, Me, Cl, F3C) have been reported. The structures of the synthesized compounds were confirmed by NMR and high resolution mass spectrometry (HRMS). All compounds were screened in vitro for their antibacterial activity against Pseudomonas aeuroginosa and Escherichia coli (Gram-neg. bacteria) and also against Staphyloccocus aureus and Eterococcus faecalis (Gram-pos. bacteria). The results showed that most of the synthesized compounds have no antibacterial activity. However, the compound I (R = 5-chloro-2-benzimidazolyl) was two-fold potent than ciprofloxacin against Staphylococcus aureus with Min. Inhibitory Concentration (MIC) of 4μg/mL and compound I (R = 5-trifluoromethyl-2-benzimidazolyl) showed moderate biol. activity against Staphylococcus aureus and Eterococcus faecalis.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Formula: C7H6BrCl) was used in this study.
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics