Electric Literature of C7H6BrClIn 2021 ,《Syntheses and Crystal Structures of Benzyl Substituted Thiazolidin-2-cyanamide Derivatives》 was published in Journal of Chemical Crystallography. The article was written by Wang, Jun-Ling; Ma, Sen; Jia, Ai-Quan; Zhang, Qian-Feng. The article contains the following contents:
Reaction of thiazolidin-2-cyanamide and substituted benzyl bromide compounds 2-R-3-R1-4-R2C6H2CH2Br (R = Me, H, CN, Br; R1 = H, Me, CN, F; R2 = H, Me, CN, F, Cl, t-Bu) in acetonitrile at room temperature afforded the 3-(2′-substituted benzyl)thiazolidin-2-cyanamide derivatives I in good yields. Compounds I were characterized by proton NMR (1H NMR) and IR spectroscopies, of which the structures of the isomeric o-, m-, and p-fluoro derivatives I (R = F, R1 = H, R2 = H; R = H, R1 = F, R2 = H; R = H, R1 = H, R2 = F) were established by single crystal X-ray crystallog. Compound I (R = F, R1 = H, R2 = H) crystallizes in the monoclinic space group P21/n, with a = 9.177(19), b = 8.551(18), c = 14.090(3) Å, β = 98.243(3)°, and Z = 4. The unit cell of I (R = H, R1 = F, R2 = H) has a monoclinic P21/c symmetry with the cell parameters a = 9.289(2), b = 14.057(4), c = 8.574(2) Å, β = 100.350(3)°, and Z = 4. The unit cell of I (R2 = FR = H, R1 = H, R2 = F) also has a monoclinic P21/c symmetry with the cell parameters a = 9.333(4), b = 14.034(5), c = 8.508(3) Å, β = 99.15(5)°, and Z = 4. A series of 3-(2′-substituted benzyl)thiazolidin-2-cyanamide derivatives I was efficiently synthesized via the reaction of benzyl bromide compounds with thiazolidin-2-cyanamide, of which the structures of the isomeric o-, m-, and p-fluoro derivatives were characterized by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics