Zhang, Meng; Wang, Fangfang; Ding, Wenjuan; Xu, Zhipeng; Li, Xiaosan; Tian, Danmei; Zhang, Youwei; Tang, Jinshan published the artcile< Synthesis of sorbicillinoid analogues with anti-inflammation activities>, Safety of (E)-Cinnamoyl chloride, the main research area is sorbicillinoid preparation antinflammatory SAR; Anti-inflammatory effects; LPS; NO production; Sorbicillinoids; Structural modification; iNOS.
The synthesis of a series of new sorbicillinoid I [R1 = R2 = R3 = H, 3-methylbut-2-enoyl, (2E,4E)-hexa-2,4-dienoyl, (E)-3-(4-chlorophenyl)prop-2-enoyl, etc.; R2 = R3 = Me] analogs was reported and assessed their anti-inflammatory activities. Results reveal that side chain substitution with (E)-2-butenoyl, (E)-3-(4-fluorophenyl)-2-propenoyl, and (E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl significantly enhanced the inhibitory effects of the derivatives on nitric oxide (NO) production and inducible NO synthesis (iNOS) expression stimulated by lipopolysaccharides (LPS) in mouse macrophage. Further chem. derivatization showed that the monomethylresorcinol skeleton worked better than the dimethylresorcinol skeleton in inhibiting LPS-induced inflammatory response in cultured cells. Among the synthesized sorbicillinoid analogs, compounds I [R1 = (E)-but-2-enoyl, R2 = R3 = Me; R1 = (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl, R2 = R3 = Me] exhibited the strongest anti-inflammatory activities, holding the promise of being developed into lead compounds that was explored as potent anti-inflammation agents.
Bioorganic & Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Safety of (E)-Cinnamoyl chloride.
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Chlorides – an overview | ScienceDirect Topics