Electric Literature of 202925-07-3, The chemical industry reduces the impact on the environment during synthesis 202925-07-3, name is 2-Chloro-1-fluoro-4-methoxybenzene, I believe this compound will play a more active role in future production and life.
10385] 1.5 g of2-methoxy-6,7,8,9-tetrahydro-5H-benzo[7] annulen-5-one were initially charged in 12 ml of THF, 2.8 g of sodium tert-butoxide, 1.20 ml of 2-chloro- 1 -fluoro-4-meth- oxybenzene and 135 mg of allylchloro[1 ,3-bis(2,6-diisopro- pylphenyl)imidazol-2-yliden]palladium(II) were added and the mixture was heated in a microwave vessel (pressure vessel) at 120 C. for 90 mm. Two analogous reactions were carried out, and the batches were combined, Water was added, and the THF was removed under reduced pressure. The residue was diluted with ethyl acetate and water, the phases were separated and the aqueous phase was extracted with ethyl acetate. The combined organic phases were washed with sodium chloride solution, dried over sodium sulphate and concentrated. Purification by column chromatography (hexane/acetone) gave 2.29 g of the title compound. C,9H,9F03 (314.36). MS (ESIpos) mass found: 314.00.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-1-fluoro-4-methoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Wintermantel, Tim; Moeller, Carsten; Bothe, Ulrich; Nubbemeyer, Reinhard; Zorn, Ludwig; Ter Laak, Antonius; Bohlmann, Rolf; Wortmann, Lars; US2015/80438; (2015); A1;,
Chloride – Wikipedia,
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