The author of 《A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen》 were Li, Zhen; Wang, Zhen; Chekshin, Nikita; Qian, Shaoqun; Qiao, Jennifer X.; Cheng, Peter T.; Yeung, Kap-Sun; Ewing, William R.; Yu, Jin-Quan. And the article was published in Science (Washington, DC, United States) in 2021. Safety of 2-Chloroisonicotinic acid The author mentioned the following in the article:
Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. IR, x-ray, and computational anal. support a possible role of ligand tautomerization from mono-anionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites. In addition to this study using 2-Chloroisonicotinic acid, there are many other studies that have used 2-Chloroisonicotinic acid(cas: 6313-54-8Safety of 2-Chloroisonicotinic acid) was used in this study.
2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of 2-Chloroisonicotinic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics