HPLC of Formula: 37908-97-7On October 8, 2020 ,《Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity》 was published in ACS Medicinal Chemistry Letters. The article was written by Uda, Junichiro; Kobashi, Seiichi; Miyata, Sachiho; Ashizawa, Naoki; Matsumoto, Koji; Iwanaga, Takashi. The article contains the following contents:
To derive new uricosuric agents, novel phenol derivatives were synthesized to overcome the disadvantages of benzbromarone (BBR), attributed by its structural features. Herein, we report the discovery of new phenol derivatives with a 1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole scaffold. The selected compound 11 (dotinurad, 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole, FYU-981, [1285572-51-1]) demonstrated remarkable inhibitory activity on uric acid uptake by primary human renal proximal tubule epithelial cells (RPTECs) and URAT1-mediated uric acid transport, with weak inhibitory activity against mitochondrial respiration. Dotinurad also displayed favorable pharmacokinetic profiles and higher potency in decreasing uric acid than BBR did in Cebus monkeys. Dotinurad has been approved as a new uricosuric medicine in Japan. Our strategy, which focuses on the structural features resulting in unfavorable effects, could be applied to the future developments of other drugs with disadvantages, particularly those having a bis-aryl ketone structure.3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7HPLC of Formula: 37908-97-7) was used in this study.
3,5-Dichloro-4-methoxybenzoic acid(cas: 37908-97-7) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. HPLC of Formula: 37908-97-7 The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics