These common heterocyclic compound, 933190-51-3, name is 8-Bromo-6-chloroimidazo[1,2-b]pyridazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
A mixture of 8-bromo-6-chloroimidazo[l,2-b]pyridazine (573 mg, 2.47 mmol), 6-(3-tert- butylpyrrolidin-l-yl)pyridin-2-amine (540 mg, 2.47 mmol), Pd2(dba)3 (142 mg, 0.25 mmol), BINAP (307 mg, 0.50 mmol), Cs2C03 (2.4 g, 7.41 mmol) and dioxane (20 mL) was heated to reflux with stirring for 15 h under N2. The solvent was removed in vacuo and the resulting mixture was purified by chromatography (silica gel, 200 – 300 mesh, dichloromethane : MeOH = 50 : 1) to give N-(6-(3-tert-butylpyrrolidin-l-yl)pyridin-2-yl)-6-chloroimidazo [l,2-b]pyridazin- 8-amine (400 mg, crude) as a brown oil. LC-MS: [M+H]+, 371.1 , tR = 2.23 min.
The synthetic route of 8-Bromo-6-chloroimidazo[1,2-b]pyridazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HERMANN, Johannes Cornelius; KUGLSTATTER, Andreas; LUCAS, Matthew C.; PADILLA, Fernando; WANNER, Jutta; ZHANG, Xiaohu; WO2013/64445; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics