Application of 2106-04-9, A common heterocyclic compound, 2106-04-9, name is 3-Chloro-2-fluoroaniline, molecular formula is C6H5ClFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Toluene (250 g) and water (150 g) were added to 50.0 g (0.34 mol) of 3-chloro-4-fluoroaniline and the mixture was heated to 60 C. Into this reaction mixture was added dropwise 50.7 g (0.36 mol) of benzoyl chloride. At the same time, a 10% aqueous sodium hydroxide solution was added dropwise thereto to maintain the pH around 8. After the dropwise addition was completed, the mixture was stirred for 2 hours and cooled in ice. The precipitate was filtered, washed with water, and dried to obtain 74.8 g of the title compound (yield: 87%) as a white solid. 1H-NMR (CDCl3, deltappm) 7.11-7.18 (2H, m), 7.50-7.61 (3H, m), 7.88-7.90 (2H, m), 8.05 (1H, brs), 8.38-8.42 (1H, m).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MITSUI CHEMICALS AGRO, INC.; Kitajima, Kazuki; Kodaka, Kenji; Katsuta, Hiroyuki; Okumura, Kunio; US2013/317247; (2013); A1;,
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