In 2022,Ishida, Toshiaki; Watanabe, Bunta; Mashiguchi, Kiyoshi; Yamaguchi, Shinjiro published an article in Phytochemistry Letters. The title of the article was 《Synthesis and structure-activity relationship of 16,17-modified gibberellin derivatives》.Related Products of 5781-53-3 The author mentioned the following in the article:
Gibberellins (GAs) are a group of diterpenoid plant hormones that control plant growth and development at various stages. Biol. active GAs share the common structures of a 3β-hydroxy group, a carboxy group at C-6, and a γ-lactone between C-4 and C-10. Hydroxylation at C-2β is a major deactivation step in many plant species, and hydroxylation at C-13 has been shown to weaken the binding affinity of GAs to their receptor proteins. In rice, bioactive GA4 has also been shown to be deactivated through 16α,17-epoxidation Moreover, 16,17-dihydro-16α,17-dihydroxy GA4 has been identified as an aglycon of its glucoside from rice. However, our knowledge on the biol. activity of 16,17-epoxidized GAs is currently limited to 16,17-dihydro-16α,17-epoxy GA4. Moreover, the bioactivity of 16,17-dihydro-16α,17-dihydroxy GA4 remains unknown. Here, we synthesized 16,17-epoxidized or dihydroxylated GA derivatives and performed a structure-activity relationship study using rice seedlings. 16,17-Epoxidation of bioactive GA1 and GA4 reduced their activity to promote elongation of rice leaf sheaths. Moreover, 16,17-dihydroxylation significantly decreased the activities of 16,17-dihydro-16α,17-epoxy GAs. These results suggest that GAs are deactivated in a stepwise manner via 16,17-epoxidation and hydrolysis of these epoxy groups. The experimental process involved the reaction of Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3Related Products of 5781-53-3)
Methyl 2-chloro-2-oxoacetate(cas: 5781-53-3) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Related Products of 5781-53-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics