Gomez-Canela, Cristian; Cortes-Francisco, Nuria; Ventura, Francesc; Caixach, Josep; Lacorte, Silvia published the artcile< Liquid chromatography coupled to tandem mass spectrometry and high resolution mass spectrometry as analytical tools to characterize multi-class cytostatic compounds>, Application of C7H17Cl2N2O3P, the main research area is cytostatic pharmaceutical determination water; liquid chromatog tandem mass spectrometry cytostatic pharmaceutical determination; high resolution mass spectrometry liquid chromatog cytostatic pharmaceutical determination.
Cytostatic compounds used for cancer treatment have emerged as a new generation of water pollutants due to the continuous amounts administered to patients and since a variable proportion is excreted unchanged. This work evaluated the performance of liquid chromatog./tandem mass spectrometry (LC/MS-MS) and high resolution mass spectrometry with an Orbitrap analyzer (LC/HRMS) for the multi-residue determination of multi-class cytostatic compounds U a first step, ionization conditions were tested in pos. electro-spray mode to determine optimum fragmentation patterns. For LC/MS-MS, 2 selected reaction monitoring (SRM) transitions were optimized; for LC/HRMS, the mol. ion with a 5 ppm error and 2 product ions were defined. Then chromatog. conditions were optimized considering the analyzed compounds have very different chem. structure and chromatog. behavior. The best performance was obtained with a Luna C18 column, which separated the 26 compounds in 15 min. Finally, LC/MS-MS and LC/HRMS performances were compared in terms of linearity, sensitivity, intra- and inter-day precision, and overall robustness. While LC/MS-MS had good identification capability due to selective SRM transitions, LC-Orbitrap was 100 times more sensitive. Results provided a comprehensive overview of MS conditions to determine the most used cytostatic compounds and a spectral library to use to identify these compounds in water or biol. matrixes.
Journal of Chromatography A published new progress about Drugs (cytostatic). 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Application of C7H17Cl2N2O3P.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics