Adding a certain compound to certain chemical reactions, such as: 72235-58-6, name is (4-Chloro-3-fluorophenyl)methanamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72235-58-6, Computed Properties of C7H7ClFN
Example 26 Preparation of Compound 26 (2S,5R,13aS)-N-(4-chloro-3-fluoroto octahydro-2,5-meth nopyri.do[1 ^2′:4,5]pyrazino[2J.-bj[l ,3joxazepme-l -carboxamide Steps 1 and 2 15~B (41 mg, 0.13 mmoi) was treated with acetonitrile (1 ml.), (4- chloro-3-fluorophenyl)methanamine (40 mg, 0.25 mmol), HATU (60 mg, 0.16 mmol), and Nu,Nu-diisopropyfethylamine (28 mg, 0.22 mmol). The reaction mixture was stirred at room temperature for one hour and magnesium bromide (48 mg, 0.26 mmol) was added. The mixture was sealed and heated to 50 C. After 60 minutes, the reaction mixture was quenched with 0.2M HCl (aq), diluted with brine, and thrice extracted into DCM. HPLC purification 0.1% TFA) afforded Compound 26. 1H- NMR (400 MHz, Chloroform-d) delta 10.41 (s, Hi), 8.30 (s, I Hi.7,24 (t, J = 6.1 Hz, H), 7.13 – 6.90 (m, 2H), 5.30 (dd, J = 9.1, 3.2 Hz, 1H), 5.22 (s, 1H), 4.61 (s, lH), 4.51 (s, 2H), 4.20 (d, J = 9.4 Hz, Hi).3.95 id. J = 12,0 Hz, 1H), 2.11 – 1.90 (m, 4H), 1.90 – 1.76 (m, 1H), 1.53 (d, J = 12.2 Hz, 1H). LCMS-ESI+ ( /z): [M+H] calculated for C21H19CIF 3O5: 448.11; found: 448.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-Chloro-3-fluorophenyl)methanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GILEAD SCIENCES, INC.; JIN, Haolun; LAZERWITH, Scott, E.; MARTIN, Teresa, Alejandra, Trejo; BACON, Elizabeth, M.; COTTELL, Jeromy, J.; CAI, Zhenhong, R.; PYUN, Hyung-Jung; MORGANELLI, Philip, Anthony; JI, Mingzhe; TAYLOR, James, G.; CHEN, Xiaowu; MISH, Michael, R.; DESAI, Manoj, C.; WO2014/100323; (2014); A1;,
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