Application of 64628-73-5,Some common heterocyclic compound, 64628-73-5, name is 3-Chloro-4-(trifluoromethoxy)aniline, molecular formula is C7H5ClF3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-Benzoyl-3-[3-chloro-4-(trifluoromethoxy)phenyl] thiourea To a stirred solution of 3-chloro-4-(trifluoromethoxy)aniline (5.00 g, 23.6 mmol) in acetone (150 mL) under nitrogen was added benzoyl isothiocyanate (3.98 mL, 29.5 mmol). The reaction was heated at 75C for 1.5 h. The cooled reaction mixture was poured into water (400 mL). The resulting precipitate was collected by filtration to give the title compound as a pale orange solid (9.0 g, quantitative yield); m/z = 374.9 (MH)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-4-(trifluoromethoxy)aniline, its application will become more common.
Reference:
Patent; ACTIVE BIOTECH AB; WELLMAR, Ulf; EAST, Stephen; BAINBRIDGE, Marie; MACKINNON, Colin; CARR, James; HARGRAVE, Jonathan; (296 pag.)WO2016/42172; (2016); A1;,
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