In 2019,ChemistrySelect included an article by Gojiya, Dinesh G.; Vekariya, Mitesh B.; Kapupara, Vimal H.; Bhatt, Tejal D.; Kalavadiya, Prakash L.; Joshi, Hitendra S.. Quality Control of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Rapid, Simple and Efficient Microwave-Assisted Alkylation of 6-Acetyl-2H-Benzo[e][1, 3]Oxazine-2,4(3H)-Dione》. The information in the text is summarized as follows:
A simple, efficient and eco-friendly method has been developed for the synthesis of biol. active alkyl derivatives of 6-acetyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione I (R = 3-n- Bu, MeC6H4, 4-O2NC6H4, etc.) by using microwave irradiations. The N-alkylation of 6-acetyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione with substituted alkyl derivatives under microwave radiations in presence of tetra-Bu ammonium bromide as a phase transfer catalyst to give the desired products. Comparison between conventional and microwave-assisted synthesis revealed that it reduced the reaction time, improve the yield and purity of 6-acetyl-3-(substituted alkyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-diones analog mols. All the final compounds were characterized by FT-IR, 1HNMR, 13CNMR, HRMS and Mass spectroscopic anal., also succeeded to develop and analyze the single crystal XRD of compound I (R = C6H5). The antimicrobial evaluation studies show moderate activities against used microbes. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Quality Control of 1-(Bromomethyl)-4-chlorobenzene) was used in this study.
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Quality Control of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics