Cheng, Qing-fang published an article in Huaxue Shiji. The title of the article was 《Improvement and synthesis of 7-amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate hdyrochloride》.Computed Properties of C21H20Cl2N2O3S The author mentioned the following in the article:
7-Amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate hydrochloride was synthesized from diphenylmethyl 7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride by condensation, N-alkylation and hydrolysis in an overall yield of 77.8%. The purity of the title compound was over 98% by HPLC. This procedure was simple, mild and safe, suitable for scale-up production(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas: 79349-53-4Computed Properties of C21H20Cl2N2O3S) was used in this study.
(6R,7R)-Benzhydryl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride(cas:79349-53-4) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C21H20Cl2N2O3S Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics