《Copper-Catalyzed Selective 1,2-Difunctionalization of N-Heteroaromatics through Cascade C-N/C=C/C=O Bond Formation》 was written by He, Qianlin; Xie, Feng; Xia, Chuanjiang; Liang, Wanyi; Guo, Ziyin; Zhu, Zhongzhi; Li, Yibiao; Chen, Xiuwen. COA of Formula: C7H6BrCl And the article was included in Organic Letters in 2020. The article conveys some information:
This study presents an efficient strategy for constructing 1,2-difunctionalized quinoline derivatives via the multicomponent cascade coupling of N-heteroaromatics with alkyl halides and different terminal alkynes. This reaction was achieved through sequential functionalization at the one- and two-positions of quinolines, which displayed a broad substrate scope, environmental friendliness, excellent functional group tolerance, high atom efficiency, and chemoselectivity. The multicomponent coupling involved the abnormal construction of new C-N, C=C, and C=O bonds in one pot. The applicability of this method was further demonstrated by the late-stage functionalization of complex drug mols. under the established conditions.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7COA of Formula: C7H6BrCl) was used in this study.
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.COA of Formula: C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics