In 2019,Organic Letters included an article by Lv, Yunhe; Pu, Weiya; Shi, Lihan. Safety of (3-Fluorophenyl)boronic acid. The article was titled 《Copper-Catalyzed Regio- and Stereoselective 1,1-Dicarbofunctionalization of Terminal Alkynes》. The information in the text is summarized as follows:
The copper-catalyzed highly regio- and stereoselective 1,1-dicarbofunctionalization of terminal alkynes is realized for the first time. Using a removable, bidentate 8-aminoquinoline auxiliary, the three-component, selective 1,1-arylalkylation of alkynes with α-haloacetamides and organoboronic acids by the addition of both alkyl and aryl groups to the terminal carbon of alkynes was achieved. Mechanistic investigations suggest that the reaction likely proceeds via the copper-catalyzed cross-coupling of terminal alkynes with α-haloamides, rearrangement, transmetalation, syn-carbocupration, and protonolysis. The experimental process involved the reaction of (3-Fluorophenyl)boronic acid(cas: 768-35-4Safety of (3-Fluorophenyl)boronic acid)
(3-Fluorophenyl)boronic acid(cas: 768-35-4) can be used to make novel liquid crystalline fluorobiphenylcyclohexenes and difluoroterphenyls by palladium-catalyzed cross-couplings also used in the synthesis of o-phenylphenols as potent leukotriene B4 receptor agonists.Safety of (3-Fluorophenyl)boronic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics