Chlorinated organic compounds are found in nearly every class of biomolecules. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Safety of 3-Bromobenzenesulfonyl chloride.
Kikkawa, Shoko;Okayasu, Misaki;Hikawa, Hidemasa;Azumaya, Isao research published ã?Effect of Halogen Bonding on Chiral Assemblies of Achiral Sulfonamide Molecules in the Crystalline Phaseã? the research content is summarized as follows. The relation between the proportion of achiral compounds that crystallize as chiral crystals and how halogen bonds affect the mol. assemblies in the crystals was studied. The influence of halogen bonding on chiral crystallization was evaluated. The systematic anal. of 76 crystal structures of secondary aromatic sulfonamides bearing halogen substituents (F, Cl, Br, and I) on the benzene rings revealed that 2 kinds of intermol. interactions play significant roles in the chiral or achiral assembly of mols. in their crystals: strong H bonds (NH···O) and weak halogen bonds (halogen···halogen, halogen···O, halogen···Ï, aromatic···aromatic, and halogen···H). The proportion of compounds that showed chiral crystallization among the halogenated compounds was lower (2.6%) than that of the nonhalogenated sulfonamides (11%). There is a correlation between the kind of contacts and the chirality of the assembly of adjacent mols. The proportion of chiral crystallization was reduced by aromatic···aromatic contacts and increased by Br···O or BrÂ·Â·Â·Ï contacts. The proportion of compounds that showed chiral crystallization among halogenated (-F, -Cl, -Br, and -I) secondary aromatic sulfonamides was lower (2.6%) than that of nonhalogenated sulfonamides (11%). The type of contacts and the chirality of assemblies of adjacent mols. are related; in particular, the probability of chiral assembly formation is reduced by aromatic···aromatic contacts and increased by Br···O or BrÂ·Â·Â·Ï contacts.
Safety of 3-Bromobenzenesulfonyl chloride, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1â?benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics