Schlauderer, Florian; Lammens, Katja; Nagel, Daniel; Vincendeau, Michelle; Eitelhuber, Andrea C.; Verhelst, Steven H. L.; Kling, Dale; Chrusciel, Al; Ruland, Juergen; Krappmann, Daniel; Hopfner, Karl-Peter published an article in 2013, the title of the article was Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase.Category: chlorides-buliding-blocks And the article contains the following content:
The authors report the crystal structure of ligand-free dimeric human MALT1casp-Ig3 in complex with the tricyclic phenothiazine derivative thioridazine. Unexpectedly, the structure reveals that the inhibitor binds in a pocket located on the opposite to the caspase active site, in the interface between the caspase domain and the Ig3 domain connecting helix α1Ig3 of MALT1. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Category: chlorides-buliding-blocks
The Article related to phenothiazine malt1 paracaspase allosteric inhibitor crystal mol structure design, antitumor multiple sclerosis enzyme inhibitor design phenothiazine derivative prepare, enantiomer resolution phenothiazine malt1 paracaspase allosteric inhibitor mol docking, cancer, inhibitors, medicinal chemistry, multiple sclerosis, thioridazine and other aspects.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics