These common heterocyclic compound, 75717-77-0, name is 2,4-Dichlorophenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H4Cl2
General procedure: A mixture of 2-bromonicotinaldehyde (9) (1 equiv, 2.68 mmol), the appropriate alkyne (1.2 equiv, 3.22 mmol), Pd(PPh3)2Cl2 (0.04 equiv, 0.11 mmol), CuI (0.07 equiv, 0.20 mmol), Et3N (1.5 equiv, 4.02 mmol), in dry DMF (16 mL), was stirred under argon atmosphere using microwave irradiation at 60C for 20 min. The reaction mixture was cooled to room temperature, quenched with Et2O (200 mL) and the solid filtered off. The organic solution was evaporated to afford a crude residue which was purified by FC (petroleum ether/AcOEt 8:2).
The synthetic route of 2,4-Dichlorophenylacetylene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Dore, Antonio; Asproni, Battistina; Scampuddu, Alessia; Gessi, Stefania; Murineddu, Gabriele; Cichero, Elena; Fossa, Paola; Merighi, Stefania; Bencivenni, Serena; Pinna, Gerard A.; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5291 – 5301;,
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