Rajan, Remya team published research in European Journal of Medicinal Chemistry in 2021 | 2905-24-0

2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Safety of 3-Bromobenzenesulfonyl chloride

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Safety of 3-Bromobenzenesulfonyl chloride.

Rajan, Remya;Schepmann, Dirk;Schreiber, Julian A.;Seebohm, Guiscard;Wuensch, Bernhard research published 《 Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring》, the research content is summarized as follows. To analyze the effect of the bioisosteric replacement of ring B of the GluN2A inhibitor TCN-201 (1) by electron-rich aromatic rings on the neg. allosteric modulation of GluN2A subunit containing NMDA receptors, four different classes of compounds I [R1 = 4-MeC6H4, 2-O2NC6H4, Bn, etc.; R2 = Bn, NHCOPh, thiophene-2-carbonylamino; X = O, S] and II [R3 = 4-MeC6H4, 3-BrC6H4, 3-Cl-4-F-C6H4] were designed and synthesized. The GluN2A channel blocking activity of the synthesized compounds was determined electrophysiol. by two-electrode voltage clamp technique. The oxazole and isoxazole derivatives I [R1 = 3-BrC6H4; R2 = Bn; X = O] and II [R3 = 3-BrC6H4, 3-Cl-4-F-C6H4] had GluN2ANMDA receptor inhibitory activity in the range of 29-40% of the lead compound TCN-201.

2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Safety of 3-Bromobenzenesulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics