Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Computed Properties of 6334-18-5.
Thorat, Nitin M.;Sarkate, Aniket P.;Lokwani, Deepak K.;Tiwari, Shailee V.;Azad, Rajaram;Thopate, Shankar R. research published 《 N-Benzylation of 6-aminoflavone by reductive amination and efficient access to some novel anticancer agents via topoisomerase II inhibition》, the research content is summarized as follows. Series of novel N-benzyl derivatives of 6-aminoflavone I (R = 3-nitrophenyl, 5-bromo-2-methoxyphenyl, quinolin-2-yl, etc.) were synthesized and evaluated for anticancer and topoisomerase II enzyme inhibition activity. All the synthesized compounds were screened for in vitro anticancer activity against human breast cancer cell line (MCF-7) and human lung cancer cell line (A-549). Among the synthesized compounds, I (R = 4-chlorophenyl (A); 4-bromophenyl (B)) were found to be the most potent anticancer agents against human breast cancer cell line (MCF-7) with IC50 values of 9.35μM and 9.58μM, resp. Compounds I (R = 4-cyanophenyl; 2,3-dichlorophenyl (C); quinolin-2-yl) exhibited promising anticancer activity against human lung cancer cell line (A-549) with 43.71%, 46.48% and 44.26% inhibition at the highest concentration of 10μM, resp. Compounds (C), (A) and (B) have ability to inhibit the topoisomerase II enzyme. Compound (A) showed most potent topoisomerase II enzyme inhibition activity with IC50 value of 12.11μM. Further, these compounds have a high potential to be developed as promising topoisomerase II inhibitors.
Computed Properties of 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics