On January 1, 2016, MacLean, Mark A.; Diez-Cecilia, Elena; Lavery, Christopher B.; Reed, Mark A.; Wang, Yanfei; Weaver, Donald F.; Stradiotto, Mark published an article.HPLC of Formula: 452-75-5 The title of the article was Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid. And the article contained the following:
N-Aryl derivatives of edaravone were identified as potentially effective small mol. inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer’s disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochem. assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).HPLC of Formula: 452-75-5
The Article related to edaravone derivative preparation palladium catalyzed protein misfolding beta amyloid, alzheimers treatment edaravone derivative beta amyloid tau aggregation inhibitor, alzheimer’s disease, beta-amyloid, hydrazine, palladium-catalyzed aminations and other aspects.HPLC of Formula: 452-75-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics