On March 28, 2021, Andrade-Sampedro, Paula; Matxain, Jon M.; Correa, Arkaitz published an article.Category: chlorides-buliding-blocks The title of the article was Pd-Catalyzed C(sp2)-H Alkoxycarbonylation of Phenethyl- and Benzylamines with Chloroformates as CO Surrogates. And the article contained the following:
Herein, an unprecedented Pd-catalyzed C(sp2)-H alkoxycarbonylation of phenylalanine derivatives and other amines featuring picolinamide as the directing group (DG) to afford the corresponding alkoxycarbonylated products, e.g., I (R = H, CO2Et), is reported. This oxidative coupling is distinguished by its scalability, operational simplicity, and avoids the use of toxic carbon monoxide as the C1 source. Remarkably, the easy cleavage of the DG enabled the efficient assembly of isoindolinone compounds D. Functional Theory calculations support a PdII/PdIV catalytic cycle. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Category: chlorides-buliding-blocks
The Article related to alkoxycarbonylated phenylalanine derivative site selective preparation, phenylalanine chloroformate alkoxycarbonylation palladium catalyst, c−h functionalization, dft calculations, alkoxycarbonylation, benzylamine, phenylalanine and other aspects.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics