On February 23, 2006, Clayton, Joshua; Ma, Fupeng; Van Wagenen, Bradford; Ukkiramapandian, Radhakrishnan; Egle, Ian; Empfield, James; Isaac, Methvin; Slassi, Abdelmalik; Steelman, Gary; Urbanek, Rebecca; Walsh, Sally published a patent.Recommanded Product: Methyl 4-bromo-2-chloro-6-methylbenzoate The title of the patent was Preparation of isoindolones as metabotropic glutamate receptor potentiators. And the patent contained the following:
The title compounds I [R1 = (un)substituted 3-7 membered ring that may contain one or more heteroatoms selected from N, O and S; R2, R3 = H, alkyl, aryl, etc.; R4, R6 = H, OH, halo, etc.; R5 = H, halo, NO2, etc.; R7 = H, halo, NO2, etc.; R8, R9 = H, halo, NO2, etc.; or, where n is greater than 1, two or more R8 and/or R9 on adjacent carbons may be absent to form an alkenyl or alkynyl moiety], useful as metabotropic glutamate receptor modulators, particularly in neurol. and psychiatric disorders, were prepared E.g., a multi-step synthesis of II, was given. Generally, compounds I were active in assays described (e.g., mGluR2 assay) at concentrations (or with EC50 values) less than 10 μM. The pharmaceutical composition comprising the compound I is disclosed. The experimental process involved the reaction of Methyl 4-bromo-2-chloro-6-methylbenzoate(cas: 877149-10-5).Recommanded Product: Methyl 4-bromo-2-chloro-6-methylbenzoate
The Article related to isoindolone preparation metabotropic glutamate receptor potentiator mglur2, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: Methyl 4-bromo-2-chloro-6-methylbenzoate
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