On February 28, 2019, Modemann, Daniel J.; Zlatopolskiy, Boris D.; Urusova, Elizaveta A.; Zischler, Johannes; Craig, Austin; Ermert, Johannes; Guliyev, Mehrab; Endepols, Heike; Neumaier, Bernd published an article.Application In Synthesis of tert-Butyl trichloroacetimidate The title of the article was 2-[ 18 F]Fluorophenylalanine: Synthesis by Nucleophilic 18 F-Fluorination and Preliminary Biological Evaluation. And the article contained the following:
2-[ 18F]Fluorophenylalanine (2-[ 18F]FPhe), a promising PET tracer for imaging of cerebral infarction and tumors, was efficiently prepared from an easily accessible iodonium salt precursor using Cu-mediated radiofluorination under ‘low base’ or ‘minimalist’ conditions. Whereas significant racemization was initially observed if the ‘minimalist’ protocol was applied for radiolabeling, it was completely suppressed by the careful adjustment of 18F -preprocessing. The initial biol. study revealed a higher uptake of 2-[ 18F]FPhe in different tumor cells in comparison to that of [ 18F]FET. In contrast to 4-[ 18F]FPhe, which suffered from rapid defluorination in vivo, 2-[ 18F]FPhe demonstrated a sufficient in vivo stability. Conclusively, 2-[ 18F]FPhe is a promising PET probe that is now readily available using Cu-mediated radiofluorination under ‘minimalist’ or ‘low base’ conditions. The simplicity of the translation of the proposed procedures to automated synthesis modules allows a broad biol. evaluation of 2-[ 18F]FPhe. Notably, a novel protocol for the preparation of N-Boc protected amino acids from the resp. Ni-Schiff base complexes was developed that avoided application of strongly acidic conditions. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application In Synthesis of tert-Butyl trichloroacetimidate
The Article related to fluorine 18 fluorophenylalanine preparation pet imaging cerebral infarction tumor, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Application In Synthesis of tert-Butyl trichloroacetimidate
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