On December 31, 2019, Kaur, Harmeet; Singh, Jasbir; Narasimhan, Balasubramanian published an article.Recommanded Product: 99-60-5 The title of the article was Indole hybridized diazenyl derivatives: synthesis, antimicrobial activity, cytotoxicity evaluation and docking studies. And the article contained the following:
In search of effective antimicrobial and cytotoxic agents, a series of indole hybridized diazenyl derivatives (DS-1 to DS-21) was efficiently prepared by condensation of diazotized p-aminoacetophenone with indole or nitroindole followed by reaction with different aromatic/heteroaromatic amines of biol. significance. The synthesized derivatives were characterized by various spectroscopic techniques. The antimicrobial evaluation of DS-1 to DS-23 was done by tube dilution method against various pathogenic bacterial and fungal strains. The active antimicrobial derivatives were further evaluated for cytotoxicity against human lung carcinoma cell line (HCT-116), breast cancer cell line (MDAMB231), leukemic cancer cell line (K562), and normal cell line (HEK293) by MTT assay using doxorubicin as the standard drug. The test derivatives were addnl. docked for the B-subunit of enzyme DNA gyrase from E. coli at the ATPase binding site to study the mol. interactions using Schrodinger maestro v11.5 software. Most of the synthesized derivatives have shown high activity against Gram-neg. bacteria particularly E. coli and K. pneumonia with MIC ranging from 1.95 to 7.81 μg/mL. The derivatives have demonstrated very less activity against tested Gram pos. bacterial and fungal strains. The derivatives DS-14 and DS-20 have been found to active against breast cancer cell line and human colon carcinoma cell line having IC50 in the range of 19-65 μg/mL. All the derivatives were found to less potent against leukemic cancer cell line. The synthesized derivatives have revealed their safety by exhibiting very less cytotoxicity against the normal cell line (HEK-293) with IC50 > 100 μg/mL. Most of the active derivatives have shown good docking scores in comparison to the standard drugs against DNA gyrase from E. coli. Further ADME predictions by Qikprop module of the Schrodinger confirmed these mols. have drug like properties. The derivatives DS-14 and DS-20 have shown potential against Gram-neg. bacteria and breast cancer cell line and can be used as a lead for rational drug designing of the antimicrobial and cytotoxic agents.[Figure not available: see fulltext.]. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 99-60-5
The Article related to escherichia staphylococcus breast cancer colon carcinoma antimicrobial cytotoxicity, antimicrobial, cytotoxicity, diazenyl, docking, indole, Placeholder for records without volume info and other aspects.Recommanded Product: 99-60-5
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