Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2106-02-7, name is 2-Chloro-4-fluoroaniline, A new synthetic method of this compound is introduced below., name: 2-Chloro-4-fluoroaniline
Lithium hexamethyldisilazide (22.9 ml, 22.9 mmol, 1 M solution in tetrahydrofuran) wasadded over 5 mm to solution of 2-chloro-4-fluoroaniline (1 .84 g, 12.6 mmol, Gas No 2106-02-7) in tetrahydrofuran (60 ml) at -780 and the mixt ure was stired at -780 for 1 h. A solution of ethyl 4-{[tert-butyl(dimethyl)silyl]oxy}- 1 -(2-ch loroethyl)cyclohexanecarboxylate (mixture of cis-/trans-isomers) (4.00 g, 11 .5 mmol) in tetrahydrofuran (60 ml) was added and the mixture was stirred for 2 h at -780 and the for 3 days at room temperature. For work-up, the reactionmixture was poured into a mixture of water and saturated sodium bicarbonate solution, extracteted with ethyl acetate (3x) and the combined organic phases were washed with brine, filtrated through a silicone filter and concentrated under reduced pressured. The residue was purified by flash chromatography (Snap Gartdidge, hexanes/ethyl acetate gradient) to give 8-{[tert-butyl(dimethyl)silyl]oxy}-2-(2-chloro-4-fluorophenyl)-2-azaspiro[4.5]decan-1 -one in 2 fractions. Fraction 1 (1.88 g, isomer 1, conatains ca 2Omol%2-chloro-4-fluoroaniline) and fraction 2 (485 mg, isomer 2).
The synthetic route of 2106-02-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERMANN, Jens; WAGNER, Sarah; BUCHGRABER, Philipp; SUeLZLE, Detlev; HOLTON, Simon; BENDER, Eckhard; LI, Volkhart; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; BAIRLEIN, Michaela; VON NUSSBAUM, Franz; HERBERT,Simon; KOPPITZ, Marcus; (734 pag.)WO2016/177658; (2016); A1;,
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