These common heterocyclic compound, 104-11-0, name is 1-(4-Chlorophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H10ClN
General procedure: A solution of benzylamine (386 mg, 3.14 mmol), dimethyl 2,2′-(carbonylbis(oxy))dibenzoate) (1009 mg, 3.06 mmol) in tetrahydrofuran (10 mL) was stirred at 20C for 2 hrs. The solvent of the reaction mixture was evaporated under reduced pressure to give a crude oil. The crude product was purified by columnchromatography (eluent: ethyl acetate : dichloromethane = 1 : 10) to afford methyl 2-((benzylcarbamoyl)oxy)benzoate (770 mg, 2.70 mmol, 88% yield (based on dimethyl2,2′-(carbonylbis(oxy))dibenzoate))) as white powder.
The synthetic route of 1-(4-Chlorophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kurouchi, Hiroaki; Otani, Yuko; Ohwada, Tomohiko; Heterocycles; vol. 93; 2; (2016); p. 705 – 713;,
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