Bladen, Chris published the artcileSynthesis and Evaluation of 1,4-Dihydropyridine Derivatives with Calcium Channel Blocking Activity, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is quinolinone hexahydro carboxylate aryl preparation calcium channel blocker; pyridine dihydro cyclohexanone fused carboxylate preparation calcium channel blocker.
1,4-Dihydropyridines (DHPs) are an important class of L-type calcium channel blockers that are used to treat conditions such as hypertension and angina. Their primary target in the cardiovascular system is the Cav1.2 L-type calcium channel isoform, however, a number of DHPs also block low-voltage-activated T-type calcium channels. Here, the synthesis of a series of novel fused dihydropyridines I (R1 = H, Me; R2 = Me, Et, i-Bu, t-Bu, PhCH2, 3-pyridylmethyl; R3 = 2,3-F2, 2-Cl-3-F3C, 2-HO-5-O2N, 2-PhCO2-5-O2N) and their abilities to block both L- and T-type calcium channels are described. Within this series of compounds, modification of a key ester moiety not only regulates the blocking affinity for both L- and T-type channels, but also allows for the development of DHPs with 30-fold selectivity for T-type channels over the L-type. The data suggest that a condensed dihydropyridine-based scaffold may serve as a pharmacophore for a new class of T-type selective inhibitors.
Pfluegers Archiv published new progress about Hantzsch cyclocondensation reaction. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde.
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Chlorides – an overview | ScienceDirect Topics