Chen, Peng-Fei published the artcileBronsted Acid Catalyzed Dearomatization by Intramolecular Hydroalkoxylation/Claisen Rearrangement: Diastereo- and Enantioselective Synthesis of Spirolactams, Related Products of chlorides-buliding-blocks, the main research area is spirolactam enantioselective diastereoselective preparation atom economy kinetic resolution; ynamide dearomatization intramol hydroalkoxylation Claisen rearrangement Bronsted acid catalyst; Brønsted acids; alkynes; cyclizations; heterocycles; kinetic resolution.
A novel Bronsted acid catalyzed intramol. hydroalkoxylation/Claisen rearrangement, allowing practical and atom-economic synthesis of a range of valuable spirolactams such as I [R1 = Ph, 4-MeC6H4, 4-F3CC6H4, etc.; R2 = Ph, 2-BrC6H4, 4-MeOC6H4, etc.; R3 = H, 8-F, 7-MeO, etc.; R4 = Ts, SO2Ph, Bs, etc.] from readily available ynamides in generally good to excellent yields with excellent diastereoselectivities and broad substrate scope was described. Importantly, an unexpected dearomatization of nonactivated arenes and heteroaromatic compounds was involved in this tandem sequence. Moreover, an asym. version of this tandem cyclization was also achieved by efficient kinetic resolution by chiral phosphoric acid catalysis. In addition, [3,3]-rearrangement was shown to be kinetically preferred over related [1,3]-rearrangement by theor. calculations
Angewandte Chemie, International Edition published new progress about [3,3]-Sigmatropic rearrangement. 99585-12-3 belongs to class chlorides-buliding-blocks, name is Methyl 4-chloro-2-methylbenzoate, and the molecular formula is C9H9ClO2, Related Products of chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics