Emam, Soha H. published the artcileDesign and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells, Product Details of C13H9ClO2, the main research area is aryloxy methoxyaryl chalcone aryloxyaryloxopropenyl coumarin preparation antiinflammatory activity; structure methoxyarylaryloxychalcone aryloxyaryloxopropenylchalcone antiinflammatory activity; inhibition nitric oxide release macrophage methoxyarylaryloxychalcone aryloxyaryloxopropenylchalcone; mol docking methoxyarylaryloxychalcone IKKbeta; Anti-inflammatory; Chalcones; LPS-induced RAW264.7 macrophages; Molecular docking; Nitric oxide inhibition; Nuclear factor kappa B.
Exaggerated inflammatory responses may cause serious and debilitating diseases such as acute lung injury and rheumatoid arthritis. Two series of chalcone derivatives were prepared as anti-inflammatory agents. (Aryloxy)methoxychalcones and (aryloxyaryl)oxopropenylcoumarins were synthesized and compared for their inhibition of COX-2 enzyme and nitric oxide production suppression. Methoxylated phenyl-based chalcones showed better inhibition to COX-2 enzyme and nitric oxide suppression than the coumarin-based chalcones. Among the 18 synthesized chalcone derivatives, I exhibited the highest anti-inflammatory activity by inhibition of nitric oxide concentration in LPS-induced RAW264.7 macrophages (IC50 = 11.2μM). I showed suppression of iNOS and COX-2 enzymes and depressed the expression of NF-κB and phosphorylated IκB in LPS-stimulated macrophages. Finally, mol. docking studies suggested the inhibition of IKKβ as a mechanism of action and highlighted the importance of hydrophobic interactions with I.
Bioorganic Chemistry published new progress about Anti-inflammatory agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Product Details of C13H9ClO2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics