Kulathooran, S. published the artcileSynthesis and biological evaluation of some new chalcones using anhydrous potassium carbonate as an efficient basic catalyst by conventional and microwave assisted techniques, Quality Control of 93118-03-7, the main research area is chalcone furanyl preparation green chem antibacterial antifungal activity SAR; aryl aldehyde furan Claisen Schmidt reaction microwave irradiation diastereoselective.
Series of novel 3-(substituted aryl)-1-(5-methylfuran-2-yl)prop-2-en-1-one derivatives I [R = 3-furanyl, 2-F-3-MeOC6H3, 3-Cl-2-FC6H3, etc.] were synthesized from com. available 2-acetyl-5-methylfuran and various substituted aromatic aldehydes in presence of anhydrous potassium carbonate in ethanol solution and by microwave irradiation method with good yield compared to conventional method. Anhydrous potassium carbonate was utilized as safe, inexpensive and efficient basic catalyst for synthesis of chalcones. The structures of the all synthesized compounds were established on the basis of IR, Mass, 1H NMR and 13C NMR. The antimicrobial activities of these derivatives were evaluated by quantifying the minimal inhibitory concentration (MIC) against various microbial strains such as Escherichia coli [ATCC-9637], Staphylococcus aureus [ATCC-25923], Klebsiella pneumonia [ATCC-13883], Candida albicans [ATCC-28366], Rhizopus arrhizus [ATCC-11145] and Aspegillus niger [ATCC-26036]. Among the tested compounds, compound I [R = 5-Me-3-indolyl] exhibited strong microbial activity against most of the microbial strains except A. niger.
International Journal of Pharmaceutical Sciences and Research published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Quality Control of 93118-03-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics