Related Products of 2106-02-7, These common heterocyclic compound, 2106-02-7, name is 2-Chloro-4-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 99 i-^-Chloro^-fluorophenylJ^-^-chloro^-fluorophenylJmethyl^S- piperazinedione (E99)Methyl [[(2-chloro-4-fluorophenyl)methyl](2-oxoethyl)amino](oxo)acetate (0.29 g, 1.0 mmol, prepared as described earlier) and 2-chloro-4-fluoraniline (0.29 g, 2.0 mmol) were dissolved in 2% acetic acid/methanol (10ml) at room temperature. The mixture was stirred for 15 minutes before polymer-supported cyanoborohydride (0.98 g, 4.0 mmol) was added. The mixture was stirred at room temperature overnight, then filtered through an SCX cartridge (Varian, 5g) and the filtrate concentrated in vacuo. The residue was then dissolved in 1-butanol (1.5 ml) and heated to 200 0C by microwave irradiation for 1 hour. The mixture was concentrated in vacuo and purified by mass-directed automated HPLC to yield 1-(2-chloro-4-fluorophenyl)-4-[(2-chloro- 4-fluorophenyl)methyl]-2,3-piperazinedione (0.161 g). LC/MS [M+H]+ = 385, retention time = 2.78 min.
The synthetic route of 2106-02-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; CHAMBERS, Laura Jane; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; STEADMAN, Jon Graham Anthony; WALTER, Daryl Simon; WO2010/125103; (2010); A1;,
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