Cakir, Gizem published the artcileNovel 4-Thiazolidinones as Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase, Related Products of chlorides-buliding-blocks, the main research area is thiazolidinone hepatitis C virus NS5B RNA dependent polymerase inhibitor; 4-Thiazolidinones; Antiviral agents; HCV NS5B polymerase; Hepatitis C; Molecular modeling.
In continuation of the authors efforts to develop new derivatives as hepatitis C virus (HCV) NS5B inhibitors, the authors synthesized novel 5-arylidene-4-thiazolidinones. The novel compounds 29-42, together with their synthetic precursors 22-28, were tested for HCV NS5B inhibitory activity; 12 of these compounds displayed IC50 values between 25.3 and 54.1 μM. Compound 33, an arylidene derivative, was the most active compound in this series with an IC50 value of 25.3 μM. Mol. docking studies were performed on the thumb pocket-II of NS5B to postulate the binding mode for these compounds
Archiv der Pharmazie (Weinheim, Germany) published new progress about Antiviral agents. 89978-31-4 belongs to class chlorides-buliding-blocks, name is 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, and the molecular formula is C8H5Cl2N3S, Related Products of chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics