Kumar, Praveen published the artcileAnticonvulsant and neurotoxicity evaluation of some novel 3-{[substituted]-amino}-2-phenyl-3H-quinazolin-4-one, Application of 4-(4-Chlorophenoxy)benzaldehyde, the main research area is anticonvulsant neurotoxicity aminophenylquinazolinone preparation structure activity.
Various 3-{[substituted]-amino}-2-phenyl-3H-quinazolin-4-one were synthesized and screened for anticonvulsant activity in maximal electroshock induced seizure (MES) and s.c. metrazol (scMET) induced seizure models in mice. The neurotoxicity was assessed using the Rotorod method. The 3-{[4-(4-Fluoro-phenoxy)-benzylidene]-amino}-2-phenyl-3H-quinazolin-4-one 7b and 3-{[4-(4-Chloro-3-methyl-phenoxy)-benzylidene]-amino}-2-phenyl-3H-quinazolin-4-one 7e emerged as the most promising compounds with anti-MES activity in mice i.p. All the compounds exhibited no neurotoxicity in Rotorod method.
International Journal of Pharmacology and Biological Sciences published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Application of 4-(4-Chlorophenoxy)benzaldehyde.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics