Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 328-84-7, name is 3,4-Dichlorobenzotrifluoride, A new synthetic method of this compound is introduced below., Recommanded Product: 328-84-7
COMPARATIVE EXAMPLE 1 Synthesis of 2,3-dichloro-5-trifluoromethylbenzaldehyde STR13 57.3 g of 3,4-dichlorobenzotrifluoride was dissolved in 500 ml of dried tetrahydrofuran under nitrogen atmosphere and was cooled down to -78 C. To the resulting solution was dropped 200 ml of 1.6M hexane solution of n-butyl lithium. After the solution was further stirred for about 1.5 hours at the same temperature, 38.9 g of DMF was added dropwise into the reaction solution. After the completion of the addition, the temperature of the reaction system was gradually elevated to room temperature, while checking the progress of the reaction. Ice water was added to the reaction solution to extract with ether. The extract was dried over anhydrous magnesium sulfate. The solvent was distilled under reduced pressure. The obtained oily product was distilled under reduced pressure to give 45.3 g of oily residue (bp. 70~85 C./2 mmHg).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Nippon Soda Co., Ltd.; US5977414; (1999); A;,
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