Guin, Avishek published the artcileTransition-Metal-Free C2-Functionalization of Pyridines through Aryne Three-Component Coupling, Product Details of C8H4ClF3O, the publication is Chemistry – A European Journal (2021), 27(55), 13864-13869, database is CAplus and MEDLINE.
The direct C2-functionalization of pyridines I (R = H, Me, Cl, pyrrolidin-1-yl, etc.) through a transition-metal-free protocol by using arynes 2-Si(CH3)3-3-R1-4-R2-5-R3-6-R4C6OS(O)2CF3 (R1 = H, Me, OMe; R2 = H, Me, F, Cl; R1R2 = -(CH2)4-, -CH=CH-CH=CH-; R3 = H, Me, F; R2R3 = -OCH2O-, -(CH2)2-, -CH=CH-CH=CH-; R4 = H, Me) multicomponent coupling is demonstrated. The reaction allowed a broad-scope synthesis of C2-substituted pyridine derivatives bearing the -CF3 group II in good yields with α,α,α-trifluoroacetophenones ArC(O)CF3 (Ar = Ph, pyren-1-yl, 1-benzothiophen-3-yl, etc.) as the third component. Activated keto esters could also be employed as the third component in this formal 1,2-di(hetero)arylation of ketones. Performing the reaction under dilute conditions inhibited the competing pyridine-aryne polymerization pathway. Nucleophilic attack by the initially generated pyridylidene intermediate on the carbonyl followed by an SNAr process resembling the Smiles rearrangement affords the desired products.
Chemistry – A European Journal published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Product Details of C8H4ClF3O.
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