Promising bio-active complexes of platinum(II) and palladium(II) derived from heterocyclic thiourea: Synthesis, characterization, DFT, molecular docking, and anti-cancer studies was written by Faihan, Ahmed S.;Hatshan, Mohammad R.;Kadhim, Mustafa M.;Alqahtani, Ali S.;Nasr, Fahd A.;Saleh, Abdulrahman M.;Al-Jibori, Subhi A.;Al-Janabi, Ahmed S.. And the article was included in Journal of Molecular Structure in 2022.Safety of Sodium tetrachloropalladate(II) The following contents are mentioned in the article:
Four platinum(II) and palladium(II) heterocyclic thiourea complexes were prepared; [Pt(CPPT)2] (1), [Pd(CPPT)2] (2), [Pt(MPPT)2] (3), and [Pd(MPPT)2] (4) (Where HCPPT = 1-(5-chloropyridin-2-yl)-3-phenylthiourea, HMPPT = 1-(3-methylpyridin-2-yl)-3-phenylthiourea). Both the ligands and the complexes were characterized by different spectroscopic techniques including: FTIR, 1H, 13C-{1H} NMR and Mass spectroscopy. The spectroscopic data anal. suggested that the complexes (1–4) adopt a square planar geometry with cis-configuration of platinum and trans- configuration of palladium complexes. Antiproliferative data indicated that palladium(II) complexes exerted a potent cytotoxic activity in comparison with platinum(II) complexes. Among all tested complexes, [Pd(MPPT)2] exhibited a promising activity with an IC50 value of 10.44 and 17.7μM against colon cancer cell lines (LoVo) and breast cancer cell lines (MCF-7), resp. Theor. calculations were applied to estimate the phys. properties and the inhibition activity of cancer cells by docking. Gaussian 09 software with 6-311G (d, p) basis set was used for theor. study. Furthermore, quantum chem. parameters of HOMO, LUMO, dipole moment, energy gap and other parameters were used to evaluate the complexes activity. MGL tools and DSV software were used to test the complexes inhibitions of breast cancer by blocking the damage cells. This study involved multiple reactions and reactants, such as Sodium tetrachloropalladate(II) (cas: 13820-53-6Safety of Sodium tetrachloropalladate(II)).
Sodium tetrachloropalladate(II) (cas: 13820-53-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of Sodium tetrachloropalladate(II)
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics