A Ratiometric and Targetable Fluorescent Sensor for Quantification of Mitochondrial Zinc Ions was written by Xue, Lin;Li, Guoping;Yu, Cailan;Jiang, Hua. And the article was included in Chemistry – A European Journal in 2012.Name: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:
The authors designed a fluorescent sensor, DQZn2 (I), for ratiometric detection of mitochondrial Zn2+. 2-Picolylamine (DPA) was employed as an ion chelator that was installed on the 2-position of a quinoline platform to achieve high selectivity for Zn2+ over biol. Na+, K+, Ca2+, and Mg2+ with 1:1 stoichiometry and high affinity with nanomolar or lower Ka values. To increase basicity of the sensor, the stronger electron donating nitrogen atom replaced the oxygen atom on 4-position of quinoline. The authors anticipated that this sensor could be protonated under neutral or even weakly basic media, and consequently would yield a resonance between quinolinium and onium resonant structures as observed for DQCd1. The resonance would lead to charge delocalization, which is more pronounced in the excited state of the mol., due to occurrence of intramol. charge transfer (ICT) in polar media. The authors envisioned that Zn2+ coordination would induce the deprotonation of the sensor and consequent inhibition of the resonance. The ratiometric measurements with distinct emission maxima shift can thus be established. Mitochondria are known to be one of sites that take up Zn2+ in living cells. The triphenylphosphonium salt (TPP), an effective mitochondrial targeting group, was thus chosen and attached to the sensor. This ratiometric approach was used for quantification of the mitochondrial free Zn2+ concentration in NIH3T3 cells. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Name: 1-Bromo-6-chlorohexane).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 1-Bromo-6-chlorohexane
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics