Chavan, Abhijit P. et al. published their research in Medicinal Chemistry Research in 2019 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: Ethyl 4-chloro-3-oxobutanoate

Synthesis of new 1,3,4-oxadiazole and benzothiazolylthioether derivatives of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-one as potential antimycobacterial agents was written by Chavan, Abhijit P.;Deshpande, Rujuta R.;Borade, Nandkumar A.;Shinde, Abhijit;Mhaske, Pravin C.;Sarkar, Dhiman;Bobade, Vivek D.. And the article was included in Medicinal Chemistry Research in 2019.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

A new series of 4-[(substituted benzylidene)-3-[(5-(pyridine-4-yl)-1,3,4-oxadiazole-2-ylthio)-methyl]]isoxazol-5(4H)-one and 4-(substituted benzylidene)-3-((benzo[d]thiazol-2-ylthio)methyl)isoxazol-5(4H)-one I and II [Ar = Ar1 = 4-methylphenyl, 4-hydroxyphenyl, 3-indolyl, etc.], resp. was synthesized. All the synthesized compounds I and II were screened for antitubercular activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis BCG (ATCC 35743) and antibacterial activity against Escherichia coli (NCIM 2576), Pseudomonas flurescence (NCIM 2059), Staphylococcus aureus (NCIM 2602), Bacillus subtilis (NCIM 2162). Amongst the synthesized 1,3,4-oxadiazole and benzothiazoyl thioether derivatives, compounds I and II [Ar = Ar1 = 4-methoxyphenyl] showed excellent antimycobacterial activity and compounds I [Ar = 4-methoxyphenyl], II [Ar1 = 4-methylphenyl, 4-hydroxyphenyl, 4-methoxyphenyl] showed excellent antibacterial activity against all tested antibacterial strains. The synthesized compounds I and II were further evaluated for their cytotoxic activity against the HCT 116 and HeLa cancer cell lines. The 1,3,4-oxadiazole and benzothiazoyl thioether derivatives I and II did not showed cytotoxicity. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics