Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives was written by Zhang, Shu-Guang;Liang, Chao-Gen;Sun, Yue-Qing;Teng, Peng;Wang, Jia-Qun;Zhang, Wei-Hua. And the article was included in Molecular Diversity in 2019.Application of 638-07-3 The following contents are mentioned in the article:
A series of novel pyrrole- and pyrazole-substituted coumarins, compounds I [R1 = H, Me, F, etc.; R2 = Me, CH2Cl, CF3, R3 = H, Me, etc.] and II [R4 = H, Me, Et, etc.; R5 = H, Me, etc.] and evaluated their antifungal activity against six phytopathogenic fungi in-vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds I [R1 = H, R2 = CH2Cl, R3 = Me] and II [R4 = H, Me, Et, R5 = Me; R4 = H’ R5 = CF3 R4R5 = (CH2)4]exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Furthermore, compound I [R1 = H, R2 = CH2Cl, R3 = Me] displayed stronger antifungal activity against Rhizoctorzia solani (EC50 = 15.4 μg/mL) than pos. control Osthole (EC50 = 67.2 μg/mL). This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application of 638-07-3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application of 638-07-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics