A near-infrared “turn-on” fluorescent probe with a self-immolative linker for the in vivo quantitative detection and imaging of hydrogen sulfide was written by Park, Chul Soon;Ha, Tai Hwan;Choi, Seon-Ae;Nguyen, Duong Nguyen;Noh, Seonmyeong;Kwon, Oh Seok;Lee, Chang-Soo;Yoon, Hyeonseok. And the article was included in Biosensors & Bioelectronics in 2017.Electric Literature of C6H5ClO2 The following contents are mentioned in the article:
Hydrogen sulfide is a critical biol. messenger, but few biol. compatible methods are available for its detection in vivo. Here, we describe the design and synthesis of a novel azide-functionalized near-IR probe, NIR-Az, for a hydrogen sulfide assay in which a self-immolative linker is incorporated between the azide moiety and phenolic dihydroxanthene fluorophore from a cyanine dye. A large “turn-on” near-IR fluorescence signal results from the reduction of the azide group of the fluorogenic moiety to an amine, in which the self-immolative linker also enhances the accessibility of NIR-Az to hydrogen sulfide. NIR-Az can select hydrogen sulfide from among 16 analytes, including cysteine, glutathione, and homocysteine. By exploiting the superior properties of NIR-Az, such as its good biocompatibility and rapid cell internalization, we successfully demonstrated its usefulness in monitoring both the concentration- and time-dependent variations of hydrogen sulfide in living cells and animals (detection limit less than 0.26μM), thereby providing a powerful approach for probing hydrogen sulfide chem. in biol. systems. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Electric Literature of C6H5ClO2).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C6H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics