Vo, Chau D. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 95-88-5

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 4-Chlororesorcinol

Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases was written by Vo, Chau D.;Shebert, Hanna L.;Zikovich, Shannon;Dryer, Rebecca A.;Huang, Tony P.;Moran, Lindsey J.;Cho, Juno;Wassarman, Douglas R.;Falahee, Bryn E.;Young, Peter D.;Gu, Garrick H.;Heinl, James F.;Hammond, John W.;Jackvony, Taylor N.;Frederick, Thomas E.;Blair, Jimmy A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Quality Control of 4-Chlororesorcinol The following contents are mentioned in the article:

To address the growing need for new antimicrobial agents, we explored whether inhibition of bacterial signaling machinery could inhibit bacterial growth. Because bacteria rely on two-component signaling systems to respond to environmental changes, and because these systems are both highly conserved and mediated by histidine kinases, inhibiting histidine kinases may provide broad spectrum antimicrobial activity. The histidine kinase ATP binding domain is conserved with the ATPase domain of eukaryotic Hsp90 mol. chaperones. To find a chem. scaffold for compounds that target histidine kinases, we leveraged this conservation. We screened ATP competitive Hsp90 inhibitors against CckA, an essential histidine kinase in Caulobacter crescentus that controls cell growth, and showed that the diaryl pyrazole is a promising scaffold for histidine kinase inhibition. We synthesized a panel of derivatives and found that they inhibit the histidine kinases C. crescentus CckA and Salmonella PhoQ but not C. crescentus DivJ; and they inhibit bacterial growth in both Gram-neg. and Gram-pos. bacterial strains. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Quality Control of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics