Highly Selective, Amine-Derived Cannabinoid Receptor 2 Probes was written by Westphal, Matthias V.;Sarott, Roman C.;Zirwes, Elisabeth A.;Osterwald, Anja;Guba, Wolfgang;Ullmer, Christoph;Grether, Uwe;Carreira, Erick M.. And the article was included in Chemistry – A European Journal in 2020.Safety of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:
The endocannabinoid (eCB) system is implied in various human diseases ranging from central nervous system to autoimmune disorders. Cannabinoid receptor 2 (CB2R) is an integral component of the eCB system. Yet, the downstream effects elicited by this G protein-coupled receptor upon binding of endogenous or synthetic ligands are insufficiently understood-likely due to the limited arsenal of reliable biol. and chem. tools. Herein, we report the design and synthesis of CB2R-selective cannabinoids along with their in vitro pharmacol. characterization (binding and functional studies). They combine structural features of HU-308 and AM841 to give chimeric ligands that emerge as potent CB2R agonists with high selectivity over the closely related cannabinoid receptor 1 (CB1R). The synthesis work includes convenient preparation of substituted resorcinols often found in cannabinoids. The utility of the synthetic cannabinoids in this study is showcased by preparation of the most selective high-affinity fluorescent probe for CB2R to date. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Safety of 1-Bromo-6-chlorohexane).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 1-Bromo-6-chlorohexane
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics