Synthetic Route of 461432-23-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of 1.6 M n-BuLi in hexanes (0.1 mL, 0.158 mmol) was added dropwise at -78 C to a stirred solution of compound 15 (50 mg, 0.158 mmol) in dry THF (2.5 mL) and the mixture was stirred at this temperature for 45 min. Then, a solution of amide 22 (100 mg, 0.158 mmol, 1 eqiv.) in THF (1 mL) was added dropwise to this mixture at the same temperature, the resulting mixture was stirred at this temperature for another 1 h, and then left at ambient temperature for 2 days. Then, the mixture was cooled in an ice bath, a saturated aqueous solution of NH4Cl (3 mL) was added and the mixture was extracted with DCM (3 * 5 mL). The combined organic layers were dried over Na2SO4, the solvent was removed under reduced pressure and the residue was chromatographed on a silica gel column (hexane/ethyl acetate 10:1) to give product 2 (45 mg, 35%) as a colorless oil.
The synthetic route of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Triantakonstanti, Virginia V.; Mountanea, Olga G.; Papoulidou, Kyriaki-Eleni C.; Andreou, Thanos; Koftis, Theocharis V.; Gallos, John K.; Tetrahedron; vol. 74; 39; (2018); p. 5700 – 5708;,
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