Optogenetic control of kinetochore function was written by Zhang, Huaiying;Aonbangkhen, Chanat;Tarasovetc, Ekaterina V.;Ballister, Edward R.;Chenoweth, David M.;Lampson, Michael A.. And the article was included in Nature Chemical Biology in 2017.SDS of cas: 6294-17-3 The following contents are mentioned in the article:
Kinetochores act as hubs for multiple activities during cell division, including microtubule interactions and spindle checkpoint signaling. Each kinetochore can act autonomously, and activities change rapidly as proteins are recruited to, or removed from, kinetochores. Understanding this dynamic system requires tools that can manipulate kinetochores on biol. relevant temporal and spatial scales. Optogenetic approaches have the potential to provide temporal and spatial control with mol. specificity. Here we report new chem. inducers of protein dimerization that allow us to both recruit proteins to and release them from kinetochores using light. We use these dimerizers to manipulate checkpoint signaling and mol. motor activity. Our findings demonstrate specialized properties of the CENP-E (kinesin-7) motor for directional chromosome transport to the spindle equator and for maintenance of metaphase alignment. This work establishes a foundation for optogenetic control of kinetochore function, which is broadly applicable to exptl. probing of other dynamic cellular processes. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 6294-17-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics