Pharmacological screening of novel indolo[2,3-b]quinoxaline derivatives was written by Pai, Nandini R.;Pusalkar, Deeptaunshu Atul. And the article was included in Journal of Chemical and Pharmaceutical Research in 2010.Formula: C6H12BrCl The following contents are mentioned in the article:
A condensation reaction of benzenediamine with isatin (1H-indole-2,3-dione) in refluxing glacial acetic acid provided indolo[2,3-b]quinoxaline. The synthesis of the target compounds was achieved by a subsequent reaction of indolo[2,3-b]quinoxaline with carbostyril derivatives [6-(haloalkoxy)-2(1H)-quinolinone and 7-(haloalkoxy)-2(1H)-quinolinone] using NaI, K2CO3, TBAB as catalyst system. The title compounds were evaluated against Gram-pos. bacteria and Gram-neg. bacteria (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli) and it was discovered that they displayed slight antibacterial activity. These compounds were also evaluated in rat models and mouse models for their antipsychotic activity (APO-induced stereotypy, DA autoreceptor agonist activity, induced catalepsy, α1-adrenoceptor antagonist activity) and it was found that these compounds displayed moderate antipsychotic activity. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Formula: C6H12BrCl).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C6H12BrCl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics