1435-48-9, name is 2,4-Dichloro-1-fluorobenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C6H3Cl2F
Add to a 2 L autoclave 194 ml (2 mol) of carbon tetrachloride and 33 g (0.2 mol) of 2,4-dichlorofluorobenzene To the reactor was added 16 g of the catalyst 8 in Table 1 above, The reaction was allowed to proceed under reflux for 30 minutes, The reactor was then cooled To room temperature, To the reaction system was added 200 ml of deionized water, Reaction at 40 C for 1 hour, After completion of the reaction, a fraction of 143-144 C (35 mmHg) was collected by distillation, To give 39.1 g of a slightly yellowish liquid, Yield 86.0%
The synthetic route of 1435-48-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang Yongtai Technology Co ., Ltd; Li, yijun; Zhang, xing; Zhou, rixi; (12 pag.)CN104649890; (2016); B;,
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